• daannii@lemmy.worldOP
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    5 hours ago

    Lsd is often distributed and consumed via small paper squares called “tabs” that’s made on blotter paper. The paper is thick like cardstock. Sometimes with colorful psychedelic artwork printed on it.

    The lsd is diluted in a solution and the paper is soaked in the solution. Usually alcohol.

    The tiny microscopic lsd crystals deposit on the paper. The blotter paper is divided into 1cm squares. Correction. 5mm squares

    Lsd is neutralized by many chemicals , including chlorine (found in tap water) and stomach enzymes. It cannot be swallowed and still have an effect. Unless mixed with other compounds

    To take LSD, a person will place squares (typically one square is 1x 100ug dose) of the paper on the tounge or under it. And hold for about 15 minutes. Some people take more than one. It can’t kill you. But it can lead to accidents in high doses that can kill you. So it’s not risk free even if health risks are low.

    Also I said ug. Not mg. The lsd drug is very unique in that it has high potency at micrograms. Fentanyl is another drug that has that property . But it is rare.

    The lining of the mouth (mucus membranes) allows for easy transfer of the drug into the blood stream. That’s true for a lot of drugs actually.

    This is why lsd has such a unique drug delivery method though. It can’t be swallowed and it should be used in very small doses.

    Lsd is also very resistant to degredation. Oxygen, sunlight, and neutralizing chemicals like chlorine can degrade it. But if it’s stored properly it can last a very very long time. This is another rare property it has.

    It’s also clear, tasteless, and no odor.

    I’m a perception researcher and , of course, this would be a drug on my radar. So I know quite a bit about it. I’ve given a lecture on psychedelics. It’s a fascinating topic.

    Also I’m generally interested in psycho-pharmacology because , well, it’s interesting.

    If you want to learn more interesting facts about LSD and other psychedelics, ask away.

    **Guy in picture has two tabs (squares of blotter paper) on his tongue and is wearing sunglasses because lsd dialates your pupils and makes your eyes sensitive to light.

    • tomiant@piefed.social
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      4 hours ago

      LSD absolutely can be swallowed, I don’t understand where all these myths come from and how they keep being propagated over decades and decades when it is a very simple thing looking it up.

      Also, LSD is not crystallizing onto blotter. It is absorbed into the paper fibers from a solution. That is not how crystallization works.

      Jesus there is more… Chlorine can degrade LSD under certain conditions, but trace chlorine in tap water does NOT reliably neutralize it in vivo.

      Lsd is also very resistant to degredation.

      LSD is chemically fragile. It degrades with light, oxygen, heat, acids, bases, and oxidizers. What you are saying is the opposite of how chemists describe LSD.

      I’m a perception researcher

      lol, sure you are.

    • BlasphemousTiefling@lemmy.ml
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      7 hours ago

      Honestly, damn. That sounds like a very interesting topic. If I wanted to learn more what resources would you recommend? (preferably textbooks/articles)

      • daannii@lemmy.worldOP
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        6 hours ago

        You know there isn’t much in a single location aside from Wikipedia.

        In textbooks I’ve come across , there is discussion of the pharmacology properties or a brief note about counter culture and general effects.

        There is limited research on the drug as it’s been black listed for almost 50 years and even now, it’s primarily only researched for terminally ill people/mental health. Only a handful of those studies exist and none use double blind controls so the science quality is poor.

        I myself am not convinced it has mental health benefits due to the way the drug works. It does however have strong suggestive effects meaning the drug itself promotes placebo/expectation effects.

        The lecture I put together for my class (perception and sensation ) pulled info from a wide range of resources.

        However there is one organization trying it’s best to do modern research and they have done some MRI studies. There was also a study on LSD and synesthesia which sheds a lot of light into the mechanisms. MAPS is the organization. https://maps.org/

        They have videos on YouTube with researchers discussing the research and studies they have done. But they mostly focus (last few years at least) on it’s use in mental health.

        The drug property information I know about is mostly pulled from old research from the 60s before the research bans. A lot was done on animals to understand dosage and half life. The cascade effects of how this drug works are still not really understood. We do know that the drug is similar in structure to serotonin. But there are still a lot of unknowns.

        Let me dig around for my resource links. I have a few interesting studies I found when preparing the lecture, including the synesthesia one, and I’ll organize it all and I’ll put a link up to a g drive with it.

        The lecture I did was 3 hrs long about hallucinations with a chunk dedicated to psychedelics. It did rely on other lecture materials to understand or otherwise id just put it up. (It was the final lecture for the class so it referred back multiple times to previous lessons). But maybe I can re-write it a bit. I’ve honestly been thinking of turning it into a video for a while because there are so few resources out there that review it more broadly. And a hell of a lot of misinformation about hallucinations and psychedelics.

        Basically this lecture was on hallucinations and the primary causes and how each of these causes relies on the same root changes in brain processing.

        For instance. You are driving on a country road at night. Vigilant to look for deer. Multiple times you were sure you saw an animal near the road but soon realized it was a fence post. Or an old glass bottle reflecting your headlamps. But for a split moment you did see an animal there before you corrected the perception.

        What ultimately caused that is what causes hallucinations in other situations. Like schizophrenia and drug use.

        So we circle around neuroscience, psychiatry, physiology, and pharmacology. As well as cultural impacts influencing the experience of hallucinations or psychedelics.

        This is getting long. Apologies. The lecture is 3 hrs and relies on many other hours of information. It’s a big topic.

    • JoeBigelow@lemmy.ca
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      11 hours ago

      Incorrect about acid in the stomach. Most DOX and nbome chems are neutralized by stomach acid and during the mid 2010 acid drought swallowing tabs was considered the simplest way to avoid unwanted DOX trips.

      Source: the hundreds of tabs that I swallowed and still had a good time

      Edit: Tons of chemicals are active on the hundred microgram scale. Most benzos, nearly all psychedelics, a handful of antipsychotics ect. And if we go active at >10mg, which is impossible to dose without a .000 scale, the list gets even bigger. I appreciate the attempt at an informative post but it’s got a few dangerous points of misinformation.

      I’m concerned that somebody giving lectures about this topic is as uninformed as you seem to be. Have you taken acid? The subjective experience is as important as the objective. It’s like listening to my cop uncle talk about weed but couched in academia.

      • Rai@lemmy.dbzer0.com
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        9 hours ago

        I took DOC back in the 00s (on purpose) and it was an extremely wild 20-some hours. Second weirdest thing I’ve done (the weirdest is Foxy by a WIDE margin,) but I still had a relatively good time due to having a great and comfortable set and setting. By hour ten, I was VERY ready to be done.

        • JoeBigelow@lemmy.ca
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          9 hours ago

          I was too poor to care, been on plenty of non acid trips on chems that lasted wayyy too long. Some were really fun, some were abject terror. Never got to try foxy sadly. MXE was the strangest chem I’ve tried and holey hell, I turned into an interdimentional worm crawling through the multiverse. It was super overwhelming.

          • Rai@lemmy.dbzer0.com
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            5 hours ago

            I never tried MXE! I wanted to as I have enjoyed ket in the past, but the times I was offered MXE, I just eas not in the right headspace/environment.

            Foxy is fucking insane. It had the normal visual and auditory hallucinations, but it’s the only thing I’ve ever tried that gave me full on temporal distortions. My partner-at-the-time and I were listening to familiar music. The music would get lower in pitch and streeeetch out, each individual note playing for longer and longer, until the tone went back to normal and the notes stopped being played for so long. When it was low and slow, our bodies got soooo heavy, we would just lay on the floor. When the notes got fast and higher pitched, our bodies would be light with energy. VERY weird stuff.

            • JoeBigelow@lemmy.ca
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              5 hours ago

              MXE and ket are really different. The hole threshold and the visual nature are way stronger ime

      • daannii@lemmy.worldOP
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        6 hours ago

        Most drugs/medicines are taken in higher doses because the body filters or neutralizes the compounds so much that only a small portion gets into the blood.

        That’s still different.

        Even if the total quantity of the drug is small in the system once it gets there, it’s not the same as how LSD works. The drug, likely because of its similarity to serotonin and size , is readily absorbed into the blood stream and passes the blood brain barrier easily. It is not filtered out to a small percentage of it’s original dose like most drugs/medicines.

        You surely are aware of this ?

        There are very few drugs that can work in small dosages like LSD. As I said, fentanyl is one.

        Drugs like DMT /Ayahuasca also can’t be ingested unless they are mixed with a maoi inhibitor.

        Most psychedelic research chemicals (nbome) are much different than lsd with different pharm and effect properties.

        It’s possible that LSD is released more quickly on the tongue than nbome drugs. So as soon as it hits the tounge the drug is delivered. I don’t think there is research on this. But I’ll look into it. I do know that the first trip was caused by a small contact of the drug on someone’s hand. That the cleaned off immediately. And it was enough time to absorb a substantial amount of the drug.
        I heard women would put on lipstick and smear LSD on the front and kiss police during protest to dose them. If That happened it might support a very fast delivery.
        I can’t find the source right now to verify the story. I’ll keep looking. Maybe I have details wrong. Maybe it was Charles Manson instructing women to do this. Does this story sound familiar to anyone ? I’ll have to find the source and verify.

        But my point is.

        This idea that it’s not neutralized in the stomach is false. There is plenty of research on that.

        • JoeBigelow@lemmy.ca
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          5 hours ago

          Look up Clonazepam, I’m not going to argue with somebody that is as confidently incorrect as you are. I have a decade and a half of subjective experience and personal research into the chemicals I have put into my body, and spent countless hours talking with people that know even more than I do. Yes, LSD is very active in small amounts. So are plenty of other chemicals and calling it unique because of that is incorrect.

          Also, stomach acid does nothing to neutralize LSD in any meaningful way, please stop saying that. You’re entire last 2 paragraphs are unsubstantiated myths and things only squares believe. The amount of LSD that Hoffman splashed on his hand likely contained thousands of doses.

          I HAVE EATEN HUNDREDS IF NOT THOUSANDS OF HITS OF LSD AND SWALLOW ALMOST EVERY SINGLE ONE OF THEM. SWALLOWING LSD DOES NOT PREVENT IT FROM WORKING. I WILL GIVE YOU TABS TO FUCKING TRY IF YOU WANT

    • captainlezbian@lemmy.world
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      7 hours ago

      Wait, is two tabs unusual? Like sure the default among my friends was one, but two is for when you really want to experience it and is more for constructive trips or to hallucinate and three is for when you need even more but you’re playing with fire there

      • daannii@lemmy.worldOP
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        6 hours ago

        I mean it depends on the person and the dose on the tabs. Like most recreational illegal drugs, it’s hard to know how much is actually present on the tabs.

        Many times drugs are diluted at various steps of transport and selling. Though it is harder to do that to a drug already on paper like this.

    • driving_crooner@lemmy.eco.br
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      12 hours ago

      They’re divided in 0.5x0.5 cm.

      You can totally eat a tab and still get high.

      Nowadays is hard to find 100ug doses. The minimum I had found is 150ug. Anything over 400ug isn’t LSD but Nbomb that is dangerous and should be avoided.

      • Rai@lemmy.dbzer0.com
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        9 hours ago

        Ugh I do not miss 25i. Put a blotter on my tongue, taste it IMMEDIATELY, spit that shit out.

        (This might have been mentioned and crooner definitely already knows this, but to others interested: LSD has zero taste at all. It just tastes like the paper it’s on (or gummy, faint grain alcohol if you’ve got a vial, etc)

        • driving_crooner@lemmy.eco.br
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          7 hours ago

          I gave up on LSD because it lasted way too long and finished not enjoying it, until talking with a friend I commented that I also hated the sour flavor of it and he was like dude that was nbomb not LSD. Then he gave me some actual LSD and it was way more pleasure experience, not as high, but didn’t extend as long and the landing was confortable.

      • daannii@lemmy.worldOP
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        6 hours ago

        Ah yes you are correct. I definitely mis reported the size. It’s 5x5mm

      • Pat_Riot@lemmy.today
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        13 hours ago

        Yes, but… it’s really hard to stay focused. Everything is kinda awesome to look at, so I have forgotten about the stars and zoned on my surroundings or my hand or a hundred other things. I like tripping in the woods or at the beach best personally.

        • daannii@lemmy.worldOP
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          5 hours ago

          Novelty is a common effect that people don’t talk about much. Essentially it makes everything seem new and novel.

          What’s interesting is, in the brain there is a specific spike in electrical activity (called event related potential, or ERP) that happens when you look at something new and unexpected. Some call it the novelty indicator. Designated P3a.

          You can measure it with eeg equipment (electrodes on the scalp).

          I’d be really interested to see if that ERP is happening more on LSD. It might shed more light on the mechanisms of the drug. If it doesn’t happen, then it would challenge the theory of what the P3a is.
          I personally think LSD has a lot of potential to be used to research perception processing in the brain.

          Too bad it’s basically impossible to get approval to use it for that reason.

          https://en.wikipedia.org/wiki/P3a